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An inspection in non-member economies by OECD inspectors will not guarantee that data generated in compliance with GLP will be accepted in other member countries than the one to which they are submitting data and which has thus sent inspectors to verify the accuracy of their compliance statement. The Klimisch score system tries to rank the reliability of toxicity studies for use by risk assessors regulatory agencies.

It was published in , by BASF a chemical company authors. When no GLP study is available for a particular endpoint, a study with a rank of 2 is usually accepted by an agency. Lower ranks typically require a new study to be performed. Klimisch scoring is very widely used in chemical risk assessments. Critics say it is a self-interested bias on objectivity, that a quality system from the regulated party gives their own GLP-complying studies the top rank.

In many instances, the optimal recommended "no-argument" means of implementing GLP is to develop an automated approach to both sample preparation and sample measurement. GLP compliance then generally entails including an overarching "chain of custody" sample history and data flow, combined with adequate standard operating procedures for calibration and linearization of measuring tools.

Jump to content Navigation. Help Learn to edit Community portal Recent changes Upload file. Download as PDF Printable version. On this Wikipedia the language links are at the top of the page across from the article title. Go to top. Contents move to sidebar hide. Article Talk. Read Edit View history. More Read Edit View history. Quality control guidelines for chemical experiments. Slovakia SNAS :.

Spain Pharmaceuticals :. The principles have been created in the context of harmonising testing procedures for the Mutual Acceptance of Data MAD. The MAD system helps to avoid conflicting or duplicative national requirements, provides a common basis for co-operation among national authorities and avoids creating non-tariff barriers to trade.

This saves the chemicals industry the expense of duplicate testing for products which are marketed in more than one country. Mutual Acceptance of Data The MAD system helps to avoid conflicting or duplicative national requirements, provides a common basis for co-operation among national authorities and avoids creating non-tariff barriers to trade.

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